Several clinical trials have found that there is no significant difference about the efficacy of analgesic at its standard doses. However, it is known that Nonsalisilat AINS drugs are superior compared to paracetamol, and salicylates for menstrual pain and bone pain.
AINS drugs are also more effective for pain, especially that is associated with inflammation (such as dental pain, sunburn, and rheumatic) when they used with anti-inflammatory doses. Paracetamol did not even have anti-inflammatory effects, only analgesics and antipyretics. It should also be remembered that the healing of pain is subjective which is influenced by various factors depending on the patient’s condition, such as previous experience and the suggestion that connect with the pain itself.
So, perhaps someone will feel that a particular analgesic is more potent than others, for a certain pain. There are several health conditions that must be considered for selecting the analgesic, such as: kidney disorders. Prostaglandin plays a role in kidney function and blood system. The risks that may occur are the occurrence of electrolyte disturbances, acute renal failure, chronic renal failure, and nephropati. These risks are often found in the use of Nonsalisilat AINS drugs for a long time.

Disease that cause pain such as headache, tootache, pain from the wound, it can be overcome with 